Measurement Science QUERI

The primary goal of the Measurement Science QUERI Program is to integrate measurement science into healthcare for Veterans. Measurement science (defined as the theory, practice, and application of suitable metrics) is at the core of VA’s Learning Healthcare System and is a critical component at every stage of the quality improvement and implementation process.

Population Health and Policy Research Group

With the growing legalization of medical and recreational marijuana in the United States, views on risks and benefits, as well as use patterns, are shifting among the adult population. Overall US adults have a more favorable view of marijuana use than is warranted by the evidence.

Evaluating the Implementation of a Novel Whole Health Pathway: A Model for Engaging Veterans in VA and Community Wellness Programs Using Telehealth and Web-Based Technology

The goal of this project is to facilitate implementation of a sustainable Whole Health Pathway that engages veterans in proactive wellness programs tailored to their personal health goals.

Heart and Soul Study

The VA and NIH-funded Heart and Soul Study is a prospective cohort study that was designed to determine how depression and other mental health conditions influence the outcomes of patients with coronary heart disease. A total of 1024 participants were enrolled between 9/00 and 12/02 and have been followed for 15 years.

Implementation of Home-Based Cardiac Rehab

Cardiac rehab programs provide an evidence-based, cost-effective intervention for risk reduction following acute myocardial infarction or coronary revascularization. Referral to cardiac rehabilitation programs is 1 of 9 published performance measures for adults with ischemic heart disease. Unfortunately, despite the compelling benefits of cardiac rehabilitation and the widespread recommendations for its use, it is vastly underutilized. Home-based CR is an emerging concept that provides a solution to this challenge.

Improving Delivery of Patient-Centered Cardiac Rehabilitation

Cardiac rehabilitation involves exercise training, education, and lifestyle counseling for patients with cardiac conditions. Home and center-based cardiac rehabilitation programs, if followed by patients, are equally effective in their benefits on risk factors, health-related quality of life, death, and clinical events following acute myocardial infarction or coronary revascularization.

Integrated Pain Management

The goal the Integrated Pain Management project is to evaluate the implementation of an Integrated Pain Team in primary care at the San Francisco VA with the goal of improving local pain care services and informing scaled-up implementation and dissemination to under-served rural clinics.

Measuring Colonoscopy Quality

Screening colonoscopy for colorectal cancer has grown exponentially in use over the past decade. With the millions of colonoscopies performed each year, quality indicators in colonoscopy have now been proposed to improve the impact of colorectal cancer screening and furthermore, are recommended to be monitored as part of an ongoing quality assurance program.

Million Veteran Program

A national research program funded by the Department of Veterans Affairs Office of Research & Development. The goal of MVP is to partner with Veterans receiving their care in the VA Healthcare System to study how genes affect health.

Mind Your Heart Study

The Mind Your Heart Study was designed to understand how posttraumatic stress disorder (PTSD) impacts physical health, particularly cardiovascular health.

Mobile Interventions for Medication Adherence

Medication adherence is one of the most important factors in achieving positive health outcomes, and new mobile technologies could prove to be imortant tools in improving medication adherence among patients.


The Patient-oriented Scalable National Network for Effectiveness Research (pSCANNER) is one of 13 Clinical Data Research Networks funded by the Patient-Centered Outcomes Research Institute as part of PCORnet. The goal of pSCANNER is to standardize electronic medical records across large healthcare organizations so that electronic health data resources can be used to answer important clinical research questions quickly and efficiently.

Quality and Appropriate Use

Dr. Keyhani’s research program includes the examination of the quality of care in the US health system and health care policy research. Her quality of care research to date has focused on examining the underuse and overuse of medical procedures, comparing receipt of appropriate therapy in different systems of care (e.g. Medicare versus Veterans Health Administration) and examining system factors that contribute to improved quality.

San Francisco Mammography Registry

The research team focuses on the epidemiology of invasive breast cancer and ductal carcinoma in situ, factors that influence the accuracy of screening mammography, improving breast cancer risk assessment and breast cancer detection, epidemiologic, biologic and genetic studies of breast density, and predictors of breast cancer recurrence. We use well characterized study populations to address our research questions.

Screening for Depression

The Whooley Questions identify patients who might benefit from further evaluation for the presence or absence of depression. They cannot be used to diagnose or measure the severity of depression. The Whooley questions simply inquire whether (during the past month) a person has often been bothered by one or both symptoms of major depressive disorder (depressed mood and/or anhedonia). 

Standardized Measurement of Functional Status

In partnership with the VA Central Office of Geriatrics and Extended Care, the “Implementation of Standardized Functional Status Measurement for Older Veterans” study seeks to improve outcomes for older Veterans by developing and implementing standardized protocols to (a) measure functional status and (b) use these measures to improve patient care.