Mary Whooley, MD

+1 415 750-2093

Mary Whooley, MD, FACP, FAHA, FAHA is a primary care physician, health services researcher, Professor of Medicine, Epidemiology & Biostatistics at the University of California, San Francisco (UCSF), and Director of Cardiac Rehabilitation at the San Francisco VA (SFVA) Health Care System. Dr. Whooley currently serves as Principal Investigator (PI) of the VA Measurement Science Quality Enhancement Research Initiative (QUERI), SFVA site-PI for the UCSF Fellowship in Clinical Informatics, and SFVA site-PI for the Million Veteran Program. She also serves as PI of a PCORI-funded study, entitled "Improving Delivery of Patient-Centered Cardiac Rehabilitation” and UCSF site-PI for the Patient-Centered Scalable National Network for Effectiveness Research (pSCANNER) project, one of 13 PCORI-funded Clinical Data Research Networks.

Dr. Whooley’s prior work focused on understanding the links between mental and physical health in patients with cardiovascular disease. She validated a simple, two-question screening instrument for depression that is commonly referred to as The Whooley Questions and used world-wide (JGIM, 1997). She also served as PI of the Heart and Soul Study, a 20-year prospective cohort study of >1000 patients with coronary heart disease. The Heart and Soul Study demonstrated that (a) depression is more strongly associated with health-related quality of life than objective measures of cardiac disease severity (JAMA, 2003) and (b) the adverse cardiovascular outcomes associated with depression are largely explained by poor health behaviors, especially physical inactivity (JAMA, 2008). Dr. Whooley has mentored numerous junior investigators and coauthored more than 200 publications.